New Route to 1-(5-Imidazolyl)ribofuranoid Glycals from Ribofuranosyl Chloride and 5-Lithio-imidazole.
نویسندگان
چکیده
منابع مشابه
1-Methyl-5-nitro-1H-imidazole
In the title compound, C(4)H(5)N(3)O(2), the nitro group is twisted with respect to the imidazole ring by a dihedral angle of 5.60 (2)°. Weak inter-molecular C-H⋯O and C-H⋯N hydrogen bonding is present in the crystal structure.
متن کامل5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-Monophosphate (AICAR), a Highly Conserved Purine Intermediate with Multiple Effects
AICAR (5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate) is a natural metabolic intermediate of purine biosynthesis that is present in all organisms. In yeast, AICAR plays important regulatory roles under physiological conditions, notably through its direct interactions with transcription factors. In humans, AICAR accumulates in several metabolic diseases, but its contribu...
متن کاملSynthesis and Structure of 1-{2,2-Dimethyl-4,6-dioxo-5-(1-pyridinio)-1,3- dioxan-5-yl}pyridinium Ylide: A New Route to Meldrum’s Acid Derivatives
Starting with its discovery [1] and correct structural assignment [2], Meldrum’s acid (1) has become a widely used reagent in organic synthesis [3]. In general, nucleophilic attack occurs at the carbonyl carbon atoms followed by ring fragmentation. Under basic conditions, the anion acts as a nucleophile itself to generate methylene Meldrum’s acid (2) derivatives. In contrast to a great number o...
متن کامل5-Bromo-1H-thieno[2,3-d]imidazole
The crystal structure of the title compound, C(5)H(3)BrN(2)S, shows that bromination of 1H-thieno[2,3-d]imidazole with N-bromo-succinimide in acetonitrile occurs at position 5 of the bicyclic system. The mol-ecule is almost planar, with a mean deviation of 0.015 Å from the least-squares plane through all the non-H atoms. In the crystal, N-H⋯N hydrogen bonds link the mol-ecules into infinite C(4...
متن کامل6. Conclusion 5. Route Planning
and the destination points are in different maps. For instance, bus-stop T3 can be reached from C1 by highway line H2 (or H1) to C3 and then by bus trip R1: S 22 (C1H2) ∧ S 34 (C3H2) ∧ T 22 (C3R1) ∧ T 23 (T3R1). Additional types of connections can be defined to express situations involving routes from a station to another. In procedural terms the previous definitions reduce to a search for inte...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1995
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.43.152